Content, Synthesis, and Function of Polyamines in Trypanosomatids: Relationship to Chemotherapy1,2

Polyamines are multiply amine‐substituted straight‐chain aliphatics; their content in different tissues may vary widely, and their functions are many. Their main routes of biosynthesis originate from ornithine and methionine. Polyamine content and biosynthesis in tryposomatid flagellates are reviewed concluding with emphasis on their possible role as critical drug targets in these parasitic protozoa so pathogenic for man in large areas of the world.