On the basis of the composition of the mineral in bone and the saturation level of blood plasma with respect to the slightly soluble calcium phosphates it is shown that normal tissue fluids are not supersaturated with whole bone but with the minerals of dead bone. The solubility controlling phase in living bone is octocalcium phosphate and the presence of this phase regulates the calcium and phosphate concentrations of the body fluids by simple physicochemical equilibrium.
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Driessens et al. (1986) studied this question.
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