Synthesis and antimicrobial activity of N-[4-(3-Oxo-3-phenyl-propenyl)-phenyl]-2-(4-phenyl-5-pyridine-4yl-4H-[1,2,4]triazole-3-ylsulfanyl)-acetamide

A new series of N-[4-(3-Oxo-3-phenyl-propenyl)-phenyl]-2-(4-phenyl-5-pyridine-4yl-4H-[1,2,4]triazole-3-ylsulfanyl)-acetamide have been synthesized by the claisen-schimodt condensation of N-(4-Acetyl-phenyl)-2-(4-phenyl-5-pyridin-4-yl-4H-[1,2,4]triazole-3-ylsulfanyl) and various aldehyde. The novel compounds structure has been established on the basis of their substituted aldehyde derivatives. All the compounds were characterized by FT-IR, Mass, and ¹H-NMR spectroscopy. These new compounds were evaluated for their in vitro antibacterial activity and anti-fungal activity.