Why the study?
Does computer quantitation of ST-segment slope and depression during maximal treadmill exercise differentiate between normal subjects and those with suspected or confirmed coronary artery disease?
Does computer quantitation of ST-segment slope and depression during maximal treadmill exercise differentiate between normal subjects and those with suspected or confirmed coronary artery disease?
Computerized quantitation of ST-segment slope and depression during exercise testing can help differentiate patients with coronary artery disease from normal subjects, even in the absence of classic ST depression.
Computerized ST analysis may aid CAD detection on exercise ECG; hypothesis-generating for prospective validation before clinical use.
The ST-segment response during maximal treadmill exercise was quantitated by digital computer after excessive noise in the electrocardiographic data was reduced by computer averaging. Both the slope and the depression were quantitated. Two groups of subjects were studied. Group A consisted of 35 subjects between 33 and 57 years of age with confirmed or suspected coronary artery disease. Group N consisted of 73 clinically normal subjects between 24 and 52 years of age. The responses of the group A subjects and the 26 subjects over age 35 in group N were compared by graphically plotting their ST slope and depression values from the last minute of exercise. A linear discriminant analysis computed from these values resulted in a line of separation between the majority of subjects in each of these two groups. This separation was accomplished even though the majority of subjects in group A did not demonstrate segmental ST depression.
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McHenry et al. (1968) studied this question.