The vaccinal efficacy of a heat-inactivated strain of Flexibacter psychroph~lus, the bacterium responsible in France for the vlsceral form of coldwater disease, was tested after intraperitoneal (IP) or bath vaccination. The level of protection was determined by the survival of fish after IP injection challenge with the live bacterium. After IP vaccination of 2.2 g fish, a relative percent survival value of 80 was obtained. Bath vaccination provided a lower but still significant protection in fish vaccinated at 50 d post-hatch or later. No protection was observed in fish vaccinated at 30 or 40 d post-hatch.
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Obach et al. (1992) studied this question.