Highly Efficient and Versatile Synthesis of Proteoglycan Core Structures from 1,6‐Anhydro‐β‐lactose as a Key Starting Material

Versatile building blocks in the form of novel derivatives of 1,6-anhydro-β-lactose have been used for the rapid and highly efficient synthesis of various proteoglycan core structures (see example). The resulting oligosaccharide–tetrapeptide conjugates can be used to investigate the mechanism of biosynthesis of glycosaminoglycans in human cartilage cells. Bn=benzyl.