Effect of Dicumarol on Ac-Globulin and Prothrombin Activity.

In human patients receiving dicumarol the plasma Ac-globulin level may be depressed by 20-50% following initiation of therapy. Individual variation was noteworthy. A gradual return to normal concentrations of Ac-globulin occurs within 3 weeks as therapy is continued and the prothrombin is maintained at a low titer. No appreciable difference from normal was found in the Ac-globulin values of patients who had been on dicumarol therapy for 1 to 14 months.