CORRELATION OF β-ENDORPHIN AND PROSTAGLANDIN E2 LEVELS IN PROSTATIC FLUID OF PATIENTS WITH CHRONIC PROSTATITIS WITH DIAGNOSIS AND TREATMENT RESPONSE

No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Nov 2001CORRELATION OF β-ENDORPHIN AND PROSTAGLANDIN E2 LEVELS IN PROSTATIC FLUID OF PATIENTS WITH CHRONIC PROSTATITIS WITH DIAGNOSIS AND TREATMENT RESPONSE ASHA R. SHAHED and DANIEL A. SHOSKES ASHA R. SHAHEDASHA R. SHAHED and DANIEL A. SHOSKESDANIEL A. SHOSKES View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)65664-9AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The chronic pelvic pain syndrome is a clinically defined symptom complex of unclear etiology. We have noted increased oxidative stress in the prostatic fluid of these patients, implying an active inflammatory response. Immune cells can produce the natural opioid β-endorphin at the site of injury, which may modulate pain. We measured β-endorphin and the inflammatory marker prostaglandin E2 in the expressed prostatic secretions of men with prostatitis, and correlated the results with symptoms. Materials and Methods: Expressed prostatic secretions samples from 70 patients and 8 asymptomatic controls were collected and frozen. β-Endorphin and prostaglandin E2 were measured by enzyme-linked immunosorbent assay. Results were stratified according to prostatitis category and compared in individuals before and after therapy. Results: In symptomatic patients β-endorphin and prostaglandin E2 were not significantly different in categories II, IIIa and IIIb expressed prostatic secretions but they were higher than in controls. The mean β-endorphin level plus or minus standard error of mean in symptomatic patients was significantly higher (23.8 ± 11 ng./ml. versus 8.7 ± 4.7, p = 0.0001) and mean prostaglandin E2 was lower (6.01 ± 2.9 ng./ml. versus 3.01 ± 2.9, p = 0.001) after successful therapy with antibiotics or antioxidant phytotherapy, Prosta-Q (Farr Laboratories, Santa Clarita, California). Conclusions: We observed a correlation of higher prostaglandin E2 and lower β-endorphin in symptomatic men with chronic prostatitis. Increased oxidative stress and inflammation may induce prostaglandin E2 production that would inhibit β-endorphin release. Treatment with therapeutic agents that decrease oxidative stress, such as antibiotics and antioxidant phytotherapy, may function at least partially by increasing β-endorphin and decreasing prostaglandin E2. 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Google Scholar Harbor-University of California-Los Angeles Medical Center, Torrance, California, and Cleveland Clinic Florida, Fort Lauderdale, Florida© 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byPontari M and Ruggieri M (2018) Mechanisms in Prostatitis/Chronic Pelvic Pain SyndromeJournal of Urology, VOL. 179, NO. 5S, (S61-S67), Online publication date: 1-May-2008.PONTARI M and RUGGIERI M (2018) MECHANISMS IN PROSTATITIS/CHRONIC PELVIC PAIN SYNDROMEJournal of Urology, VOL. 172, NO. 3, (839-845), Online publication date: 1-Sep-2004.SHOSKES D, LANDIS J, WANG Y, NICKEL J, ZEITLIN S and NADLER R (2018) IMPACT OF POST-EJACULATORY PAIN IN MEN WITH CATEGORY III CHRONIC PROSTATITIS/CHRONIC PELVIC PAIN SYNDROMEJournal of Urology, VOL. 172, NO. 2, (542-547), Online publication date: 1-Aug-2004.SHOSKES D, HAKIM L, GHONIEM G and JACKSON C (2018) Long-term Results of Multimodal Therapy for Chronic Prostatitis/chronic Pelvic Pain SyndromeJournal of Urology, VOL. 169, NO. 4, (1406-1410), Online publication date: 1-Apr-2003.Shoskes D, Albakri Q, Thomas K and Cook D (2018) Cytokine Polymorphisms in Men with Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Association with Diagnosis and Treatment ResponseJournal of Urology, VOL. 168, NO. 1, (331-335), Online publication date: 1-Jul-2002. Volume 166Issue 5November 2001Page: 1738-1741 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.KeywordsprostatitisendorphinsquercetinprostateMetricsAuthor Information ASHA R. SHAHED More articles by this author DANIEL A. SHOSKES More articles by this author Expand All Advertisement PDF downloadLoading ...