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January 1, 2011Journal of Atherosclerosis and Thrombosis25 citationsOpen Access

Resveratrol Inhibits Monocytic Cell Chemotaxis to MCP-1 and Prevents Spontaneous Endothelial Cell Migration Through Rho Kinase-Dependent Mechanism

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Why the study?

Does resveratrol reduce endothelial cell migration and monocytic cell chemotaxis in vitro?

Population

Human umbilical vein endothelial cells (HUVECs) and THP-1 monocytic cells

Comparison

Resveratrol (1-20 µmol/L) in vitro vs Untreated or ethanol-treated control cells

Design

Preclinical

Follow-up

up to 27 hours

Key result

Resveratrol dose-dependently inhibited spontaneous endothelial cell migration and MCP-1-induced monocytic cell chemotaxis in vitro.

Authors

ICIwona CichaMRMelanie ReglerKUKatharina Urschel

Discussion

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Member takes

Overview

Hypothesis-generating for resveratrol in atherosclerosis; clinical translation untested and should not change practice.

Structured PICO

Does resveratrol reduce endothelial cell migration and monocytic cell chemotaxis in vitro?

P
Population
In vitro study using human umbilical vein endothelial cells and THP-1 monocytic cells to investigate the effects of resveratrol on cell migration and chemotaxis.
I
Intervention
Resveratrol (1-20 µmol/L) in vitro
C
Comparator
Untreated or ethanol-treated control cells
O
Outcome
Endothelial cell migration (assessed in a modified barrier assay) and monocytic cell chemotaxis towards MCP-1 (assessed using a Boyden chamber)surrogate

Resveratrol dose-dependently inhibits endothelial cell migration and MCP-1-induced monocytic cell chemotaxis in vitro, highlighting a potential mechanism for its cardioprotective and anti-atherosclerotic effects.

Main Result

p-value: p=<0.05

Limitations

  • In vitro study design
  • Concentrations used in the study may be higher than those typically achievable through red wine consumption alone

Cite This Study

Cicha et al. (2011) studied Atherosclerosis (in vitro models). Resveratrol vs. Control (untreated or ethanol-treated) was evaluated on Endothelial cell migration and MCP-1-induced monocytic cell chemotaxis (p=<0.05). Resveratrol dose-dependently inhibited spontaneous endothelial cell migration and MCP-1-induced monocytic cell chemotaxis in vitro.

synapsesocial.com/papers/6a71abca2163a0a01bc5b853https://doi.org/10.5551/jat.8136
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