Population
Normal and cardiac lethal mutant (recessive mutant gene c) Mexican axolotl (Ambystoma mexicanum) embryos
Comparison
Immunofluorescence studies for myosin… vs Normal vs mutant siblings
Design
Preclinical
Authors
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Axolotl mutant phenotype warrants no clinical change; leaves open sarcomeric protein roles in human myofibrillogenesis.
Cardiac lethal mutant axolotl embryos lack normal myofibril organization, showing reduced and non-filamentous myosin, significant alpha-actinin, and very little tropomyosin.
Lemanski et al. (1980) studied this question.
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