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A multiple covalent crosslinked gel of poly(acrylamide-acrylic acid) was synthesized by using acrylic acid and acrylamide both as a comonomer and as a covalent crosslinker. The resultant gel showed a high crosslinking degree, tight micropores, but similar softness and marked separation capacity, in contrast to traditional polyacrylamide gels. The gel might serve as a novel matrix in bioseparation.
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Liu et al. (2016) studied this question.
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