Key result
Maternal preeclampsia exposure was associated with higher unadjusted adolescent SBP compared to normotensive pregnancies (115.3 vs. 113.5 mmHg, P=0.03), but no difference in DBP (P=0.10).
Cohort (n=537)
OBJECTIVE: To compare blood pressure (BP) in adolescence (11-12 years) among the offspring of preeclamptic and normotensive pregnancies. METHOD: SBP and DBP of 181 girls and boys born after pregnancies with preeclampsia were measured and compared with the BP of 356 age-matched girls and boys of normotensive pregnancies. The association of preeclampsia with later BP was adjusted for perinatal information, anthropometric factors at follow-up, and maternal BP and BMI. RESULTS: In the preeclampsia group, SBP in early adolescence was higher than in the normotensive group (115.3 vs. 113.5 mmHg, P = 0.03), but there was no difference in DBP (66.4 vs. 65.3 mmHg, P = 0.10). After adjustment for maternal body mass and BP, the difference in SBP was largely attenuated. CONCLUSION: The higher SBP among adolescent offspring of preeclamptic pregnancies could be mediated by maternal body mass or BP, factors that are positively associated with the risk of preeclampsia in pregnancy.
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Øglænd et al. (2009) conducted a cohort in Maternal preeclampsia exposure and adolescent blood pressure (n=537). Maternal preeclampsia vs. Normotensive pregnancy was evaluated on Systolic blood pressure (SBP) and diastolic blood pressure (DBP) in early adolescence (mmHg) (p=0.03). Maternal preeclampsia exposure was associated with higher unadjusted adolescent SBP compared to normotensive pregnancies (115.3 vs. 113.5 mmHg, P=0.03), but no difference in DBP (P=0.10).
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