Key result
Human PIEZO1 channels are non-selective cation channels permeable to monovalent and most divalent ions, with a conductance sequence of K+ > Cs+ ≈ Na+ > Li+ and an estimated pore diameter of ~8 Å.
Population
HEK293 cells transiently transfected with human PIEZO1 (hPIEZO1) cDNA
Design
Preclinical
Authors
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Should not change clinical practice; leaves open PIEZO1's cardiovascular roles pending functional studies.
This basic science study defines the ionic selectivity and pore dimensions of human PIEZO1 channels, which are critical for understanding their mechanotransduction role in physiology and disease.
Gnanasambandam et al. (2015) studied None (In vitro study of hPIEZO1 channels). Various monovalent and divalent cations vs. K+ (reference ion) was evaluated on Single-channel conductance and permeability ratios. Human PIEZO1 channels are non-selective cation channels permeable to monovalent and most divalent ions, with a conductance sequence of K+ > Cs+ ≈ Na+ > Li+ and an estimated pore diameter of ~8 Å.
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