Key result
Adipocyte dysfunction and pathological communications between adipocytes and cardiomyocytes play important roles in diabetic cardiac injury.
Why the study?
The molecular basis linking diabetes with cardiovascular complications is not yet fully defined, with emerging evidence implicating adipocyte-cardiomyocyte communications in diabetic cardiac injury.
Adipocyte-cardiomyocyte communication is an important emerging mechanism in diabetic cardiac injury.
Cardiovascular disease is the leading cause of morbidity in patients with diabetes mellitus. In 2019, the American Heart Association and the American Diabetes Association (along with industry leaders) launched the groundbreaking collaborative initiative "Know Diabetes by Heart™" to reduce cardiovascular deaths in type 2 diabetic patients. The molecular basis linking diabetes with cardiovascular complications has not yet been fully defined. Recent clinical and experimental studies strongly suggest that adipocyte dysfunction and subsequent pathological communications between adipocyte and cardiomyocytes play important roles in diabetic cardiac injury. This perspective article will review recent development concerning adipocyte-cardiomyocyte communications, and identify the most critical questions remain to be answered in this filed.
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Wang et al. (2021) conducted a review in Diabetes mellitus with cardiovascular complications. Adipocyte-cardiomyocyte communications was evaluated. Adipocyte dysfunction and pathological communications between adipocytes and cardiomyocytes play important roles in diabetic cardiac injury.
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