Key result
In healthy urban residents, high resting double product was positively associated with insulin resistance in women (OR 3.55) and negatively associated with high amounts of exercise in men (OR 0.22).
Why the study?
The study aimed to investigate the determinants of high double product by evaluating associations between resting double product, blood test results, and lifestyle factors.
What are the determinants of high double product in healthy urban residents?
Cross-Sectional (n=973)
What are the determinants of high double product in healthy urban residents?
High double product at rest is associated with insulin resistance, gamma-glutamyl transferase levels, and lower exercise amounts in healthy individuals, suggesting these factors as potential targets for primary cardiovascular prevention.
Answers are grounded in this paper and cite their sources.
High resting double product may signal sex-specific risks in healthy adults; hypothesis-generating and should not yet change practice.
BACKGROUND: The current study aimed to investigate the determinants of high double product (DP) by evaluating the association between resting DP, which is calculated as systolic blood pressure (SBP) multiplied by heart rate (HR), and blood test results and lifestyle factors. METHODS: This research included 973 participants in the baseline survey of the KOBE study, which included a cohort of urban residents. The possible DP determinants were identified by examining the association between lifestyle factors and laboratory findings and DP by analyzing covariance adjusted for sex and age. Logistic regression analysis was performed with high DP (SBP × HR ≥ 9145 mmHg beats/min or quintile according to sex) as outcome and DP determinants as independent variables. RESULTS: Age, hematocrit, and gamma-glutamyl transferase (log) level were positively associated with a high DP in both men and women. In addition, a high DP was positively associated with Homeostatic Model Assessment for Insulin Resistance score in women alone. Meanwhile, the amount of exercise was negatively associated with a high DP in men alone. CONCLUSIONS: High DP values at rest were associated with insulin resistance, gamma-glutamyl transferase, and the amount of exercise in participants without underlying disease.
No takes yet. Share an insight, caveat, or question.
Nakagoshi et al. (2023) conducted a cross-sectional in Healthy urban residents (n=973). Insulin resistance (HOMA-IR) vs. Lower HOMA-IR levels was evaluated on High double product (≥ 9145 mmHg × beats/min) (OR 3.55, 95% CI 2.03-6.22). In healthy urban residents, high resting double product was positively associated with insulin resistance in women (OR 3.55) and negatively associated with high amounts of exercise in men (OR 0.22).
Synapse has enriched 10 related papers. Consider them for comparative context: