Key result
A history of cerebrovascular disease combined with a lack of physical activity habits significantly increased the risk of functional disability (HR 2.65) compared to individuals without a history of cerebrovascular disease who maintained physical activity habits.
Why the study?
The study examined the impact of a history of coronary artery disease or cerebrovascular disease and physical activity habits on functional disability among community-dwelling adults.
Does a physical activity habit reduce the incidence of functional disability in community-dwelling adults with and without a history of cardiovascular disease?
Cohort (n=10,661)
No
Does a physical activity habit reduce the incidence of functional disability in community-dwelling adults with and without a history of cardiovascular disease?
Hazard Ratio: 2.65 (95% CI 1.49–4.71)
p-value: p=<0.001
Physical activity habits are associated with a reduced risk of functional disability in older adults, regardless of a prior history of coronary artery or cerebrovascular disease.
May elevate disability risk in cerebrovascular disease; hypothesis-generating and should not yet change practice.
We examined the impact of a history of coronary artery disease (CAD) or cerebrovascular disease (CVD) and physical activity habits on functional disability among community-dwelling Japanese adults. This population-based retrospective cohort study included 10,661 people aged 39-98 years in Japan (5054, men). Median follow-up was 3.7 years. During the study period, 209 functional disabilities occurred in the overall study population. In multivariable analysis, a history of CVD (hazard ratio [HR] 1.57 [95% CI: 1.00-2.45]) and no physical activity habit (HR 1.74 [1.27-2.39]) presented increased risks for functional disability. HRs for functional disability among patients with a CVD history with and without a physical activity habit were 1.68 (0.75-3.74) and 2.65 (1.49-4.71), respectively, compared with individuals without a history of CVD with a physical activity habit. Similar results were observed for CAD. We found no significant difference in the incidence of functional disability between the group with a history of CAD or CVD and physical activity habits and the group with no history of CAD or CVD and without physical activity habits. Physical activity habits had a favorable influence on avoiding functional disability regardless of a history of CAD or CVD. Future prospective studies are needed to clarify these associations.
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Kodera et al. (2023) conducted a cohort in Functional disability (n=10,661). History of cerebrovascular disease without physical activity habits vs. No history of cerebrovascular disease with physical activity habits was evaluated on Incidence of functional disability (HR 2.65, 95% CI 1.49-4.71, p=<0.001). A history of cerebrovascular disease combined with a lack of physical activity habits significantly increased the risk of functional disability (HR 2.65) compared to individuals without a history of cerebrovascular disease who maintained physical activity habits.
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