Cardio-Ankle Vascular Index (CAVI) Measurement of Arterial Stiffness Associated with Cardiovascular Disease Risk Factors in Type 2 Diabetes Patients

Cardiovascular disease (CVD) is common occur in type 2 diabetes mellitus (T2DM) patients.We aim to evaluate the association of cardioankle vascular index (CAVI) with the CVD risk factors.Anthropometric and CAVI measurements, blood pressure (BP) and biochemical variables were measured.One hundred and eighty seven women were allocated to 2 groups.Group (Gr)-1; 56T2DM patients with CAVI>0.9 were significantly higher in age, BP, mean arterial pressure (MAP), fasting blood sugar (Glu), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C), hs-CRP, insulin, insulin resistance (HOMA-IR) and significantly lower in BMI, high density lipoprotein (HDL-C)levels than Gr-2; 131 non-T2DM subjects with CAVI<0.9.In bivariate correlation, CAVI was significantly correlated with Age, BMI, MAP, TC, HDL-C and hs-CRP (p<0.05).Multiple forward stepwise linear regression analyses of the significant variables showed that the independent predictors of CAVI were Age (b=0.448,R 2 =0.406, p<0.001), hs-CRP (b=0.220,R 2 =0.507, p<0.001),BMI (b=-0.383,R 2 =0.545, p<0.001),HDL-C (b=-0.350,R 2 =0.484, p<0.001),TC (b=0.256,R 2 =0.508, p<0.001) and MAP (b=0.248,R 2 =0.524, p<0.001).CAVI was associated with CVD risk factors and can be used as a CVD risk factor in T2DM patients.CAVI measurement is a useful tool to assess arterial stiffness and evaluate for subclinical coronary atherosclerosis in asymptomatic patients.