Non-destructive real-time reaction monitoring in solid phase synthesis by near-infrared reflectance spectroscopy—esterification of a resin-bound alcohol

Near-infrared (NIR) reflectance spectroscopy has been used to monitor the chemical inter-conversion of resin-bound functional groups. Measurements required no sample preparation and were made directly through the bottom of the glass reaction vessel. The time–concentration profile of the esterification of a resin-bound alcohol by acetic anhydride in a toluene medium is demonstrated.