The efficacy and toxicity of cefoxitin sodium and cephalothin have been compared in a clinical study. For 50 patients treated with cefoxitin and 35 treated with cephalothin, clinical response was favourable in 86% and 68% respectively. Cephalothin was not effective in the treatment of anaerobic Gram-negative infections. Cefoxitin was effective in the treatment of septicaemia, osteomyelitis, pulmonary infections, and pyelonephritis caused by cephalothin-resistant organisms. Cefoxitin was also effective in the treatment of infections by the anaerobic pathogen Bacteroides . No major haematologic, hepatic, or renal toxicity was encountered in patients treated with either drug.
No takes yet. Share an insight, caveat, or question.
Jahre et al. (1978) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: