Concentrations of norepinephrine in lower brainstem and hypothalamus of genetically hypertensive rats are significantly lower than in control rats. There is a concomitant reduction (50 percent) in aromatic L-amino acid decarboxylase but not in tyrosine hydroxylase activity. A possible relation of this central catecholamine deficiency to the hypertension is discussed.
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Yamori et al. (1970) studied this question.
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