Key result
Vancomycin was identified as the sole etiologic factor for biopsy-proven nephrotoxic acute tubular necrosis in a single patient case.
Case Report (n=1)
This case report provides evidence that vancomycin can act as the sole etiologic factor for nephrotoxic acute tubular necrosis.
Vancomycin merits consideration in ATN differentials; single case leaves open need for confirmatory studies.
Vancomycin (VAN) has been associated with acute kidney injury (AKI) since it has been put into clinical use in the 1950's. Early reports of AKI were likely linked to the impurities of the VAN preparation. With the advent of the more purified forms of VAN, the incidence of AKI related to VAN were limited to acute interstitial nephritis (AIN) or as a potentiating agent to other nephrotoxins such as Aminoglycosides. VAN as the sole etiologic factor for nephrotoxic acute tubular necrosis (ATN) has not been described. Here, we report a case of biopsy-proven ATN resulting from VAN.
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Shah‐Khan et al. (2011) conducted a case report in Acute Tubular Necrosis (n=1). Vancomycin was evaluated on Biopsy-proven acute tubular necrosis. Vancomycin was identified as the sole etiologic factor for biopsy-proven nephrotoxic acute tubular necrosis in a single patient case.
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