Evaluation of the Role of Toxicological Data in Discriminating Between H₂S Femoral Blood Concentration Secondary to Lethal poisoning and Endogenous H₂S Putrefactive Production

Hydrogen sulfide is a colorless gas and has a strong odor of rotten eggs. It is absorbed by the upper respiratory tract mucosa, and it causes histotoxic hypoxemia and respiratory depression by exerting an inhibitory effect on cytochrome oxidase. To evaluate the role of toxicological data in distinguishing between the H 2 S blood concentration secondary to lethal poisoning and the endogenous H 2 S produced during putrefaction, we compared the postmortem H 2 S concentrations of six fatal H 2 S poisoning cases (8.7–28.6 mg/L) with the postmortem concentrations of endogenous H 2 S of 12 subjects who died from other causes (traffic‐related deaths) (2.2–32.7 mg/L). These results will be of interest to the forensic community as it underlines the importance of considering circumstantial evidence along with the toxicological and pathological findings in the identification of H 2 S lethal poisoning.