What question did this study set out to answer?

To examine the contribution of nitric oxide to Borna disease neuropathogenesis by measuring inducible and constitutive nitric oxide synthase expression in infected rat brains.

October 1, 1993Journal of VirologyOpen Access

Severity of neurological signs and degree of inflammatory lesions in the brains of rats with Borna disease correlate with the induction of nitric oxide synthase

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To examine the contribution of nitric oxide to Borna disease neuropathogenesis by measuring inducible and constitutive nitric oxide synthase expression in infected rat brains.
Measured temporal expression of inducible nitric oxide synthase (iNOS) and constitutive nitric oxide synthase (cNOS) mRNA in Borna disease virus (BDV)-infected and uninfected rat brains.
Used in situ hybridization and immunohistochemistry to map the spatial and cellular distribution of iNOS mRNA and iNOS-positive cells across brain regions.
iNOS mRNA was undetectable in healthy brains but emerged at 14 days postinfection and reached maximum levels at 21 days postinfection, coinciding directly with peak neurological signs and brain inflammation.
cNOS mRNA, detectable in uninfected brains, increased markedly at 17 days postinfection and also peaked at 21 days postinfection.
iNOS mRNA and iNOS-positive monocyte/macrophage-like cells localized selectively to inflammatory lesions in the basolateral cortex and perivascular hippocampal regions.

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Implication

Experimental study shows nitric oxide synthase induction mirrors brain inflammation and neurological signs in rats, suggesting nitric oxide drives Borna disease pathogenesis.

Cite This Study

Zheng et al. (1993) studied this question.

synapsesocial.com/papers/6a71c2ba31a3df824329cc19 https://doi.org/10.1128/jvi.67.10.5786-5791.1993

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Implication

Experimental study shows nitric oxide synthase induction mirrors brain inflammation and neurological signs in rats, suggesting nitric oxide drives Borna disease pathogenesis.

Severity of neurological signs and degree of inflammatory lesions in the brains of rats with Borna disease correlate with the induction of nitric oxide synthase

Key Points

Discussion

Implication

Cite This Study

Severity of neurological signs and degree of inflammatory lesions in the brains of rats with Borna disease correlate with the induction of nitric oxide synthase

Key Points

Discussion

Implication

Cite This Study

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