Key result
CNP is the dominant natriuretic peptide in mouse and human submandibular glands, and abnormal ectopic expression of NPRA was identified in the stroma of a subset of glands from patients with oral squamous cell carcinoma.
Observational (n=8)
Ectopic NPRA expression in OSCC stroma is hypothesis-generating; leaves open any diagnostic or therapeutic role pending prospective validation.
The natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy murine and human submandibular salivary glands (SMGs). We show CNP is the dominant NP in mouse and human SMG and is expressed together with NP receptors in ducts, autonomic nerves and the microvasculature of the gland, suggesting CNP autocrine signalling may take place in some of these glandular structures. These data suggest the NP system may control salivary gland function during homeostasis through the regulation of electrolyte re-absorption, neural stimulation and/or blood vessel wall contraction/relaxation. We also show abnormal expression of NPRA in the stroma of a subset of human SMGs resected from patients diagnosed with oral squamous cell carcinoma (OSCC) of non-salivary gland origin. This finding warrants further research to investigate a possible correlation between early OSCC invasion and NPRA overexpression.
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Ahmed et al. (2019) conducted an observational in Healthy and Oral Squamous Cell Carcinoma (n=8). Oral squamous cell carcinoma (OSCC) vs. Normal submandibular glands was evaluated on Expression and spatial distribution of natriuretic peptides and their receptors. CNP is the dominant natriuretic peptide in mouse and human submandibular glands, and abnormal ectopic expression of NPRA was identified in the stroma of a subset of glands from patients with oral squamous cell carcinoma.
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