Key result
Adverse adiposity variants (UFA) increased the risk of cardiometabolic diseases, whereas favorable variants (FA) were protective and associated with lower liver fat.
Why the study?
The study was conducted to understand the causal role of adiposity and ectopic fat in type 2 diabetes and cardiometabolic diseases by identifying unfavorable versus favorable metabolic adiposity genetic variants.
Do different adiposity genetic variants (favorable vs unfavorable) have opposing effects on ectopic fat distribution and the risk of cardiometabolic diseases?
Population
Individuals from UK Biobank
Comparison
Unfavorable adiposity variants vs favorable adiposity variants
Design
Multivariate genome-wide association study and Mendelian randomization study
Authors
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May refine cardiometabolic risk stratification beyond BMI; hypothesis-generating for favorable adiposity pathways.
Observational
Do different adiposity genetic variants (favorable vs unfavorable) have opposing effects on ectopic fat distribution and the risk of cardiometabolic diseases?
Distinct genetic adiposity phenotypes exist, where 'favorable' adiposity variants protect against cardiometabolic disease and are associated with lower liver fat, contrasting with 'unfavorable' variants.
Martin et al. (2021) conducted an observational in Type 2 diabetes and cardiometabolic diseases. Adiposity genetic variants (UFA and FA) was evaluated on Risk of type 2 diabetes, heart disease, hypertension, stroke, nonalcoholic fatty liver disease, and polycystic ovary syndrome. Adverse adiposity variants (UFA) increased the risk of cardiometabolic diseases, whereas favorable variants (FA) were protective and associated with lower liver fat.
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