Key result
Kidney transplantation significantly improved left ventricular global longitudinal strain from -13.4% at baseline to -15.2% at 6 months, which was associated with reverse remodeling.
Why the study?
It was unknown whether LV global longitudinal strain measured by feature-tracking CMR improves after kidney transplantation and how it relates to reverse remodeling and myocardial tissue characteristics.
Does kidney transplantation improve left ventricular global longitudinal strain measured by FT-CMR in patients with end-stage renal disease?
Cohort (n=44)
No
Does kidney transplantation improve left ventricular global longitudinal strain measured by FT-CMR in patients with end-stage renal disease?
Kidney transplantation is associated with significant improvement in left ventricular global longitudinal strain and reverse remodeling at 6 months, though values remain impaired compared to healthy controls.
To determine whether left ventricular (LV) global longitudinal strain (GLS) measured by feature-tracking (FT) cardiac magnetic resonance (CMR) improves after kidney transplantation (KT) and to analyze associations between LV GLS, reverse remodeling and myocardial tissue characteristics. This is a prospective single-center cohort study of kidney transplant recipients who underwent two CMR examinations in a 3T scanner, including cines, tagging, T1 and T2 mapping. The baseline exam was done up to 10 days after transplantation and the follow-up after 6 months. Age and sex-matched healthy controls were also studied for comparison. A total of 44 patients [mean age 50 ± 11 years-old, 27 (61.4%) male] completed the two CMR exams. LV GLS improved from - 13.4% ± 3.0 at baseline to - 15.2% ± 2.7 at follow-up (p < 0.001), but remained impaired when compared with controls (- 17.7% ± 1.5, p = 0.007). We observed significant correlation between improvement in LV GLS with reductions of left ventricular mass index (r = 0.356, p = 0.018). Improvement in LV GLS paralleled improvements in LV stroke volume index (r = - 0.429, p = 0.004), ejection fraction (r = - 0.408, p = 0.006), global circumferential strain (r = 0.420, p = 0.004) and global radial strain (r = - 0.530, p = 0.002). There were no significant correlations between LV GLS, native T1 or T2 measurements (p > 0.05). In this study, we demonstrated that LV GLS measured by FT-CMR improves 6 months after KT in association with reverse remodeling, but not native T1 or T2 measurements.
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Barbosa et al. (2021) conducted a cohort in End-stage renal disease (n=44). Kidney transplantation vs. Baseline (up to 10 days post-transplant) was evaluated on Left ventricular global longitudinal strain (LV GLS) (p=<0.001). Kidney transplantation significantly improved left ventricular global longitudinal strain from -13.4% at baseline to -15.2% at 6 months, which was associated with reverse remodeling.
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