Insulin Mediators: Structure and Formation

In two previous papers (Larner et al. 1979b, 1981), we have described our work on the mechanism of insulin action to control glycogen synthesis via the generation of mediators that control the covalent phosphorylation state. Several laboratories have continued a series of intensive investigations aimed at elucidating insulin's mechanism of action. These have included studies on the insulin receptor tyrosine kinase activity, activation of serine protein kinases by insulin, and the formation of insulin mediators as potential portions of insulin's signaling pathway.