Key result
Moderate heart rate reduction induced cardiomyocyte proliferation and promoted cardiac regenerative repair after myocardial injury by activating glucose metabolism.
Why the study?
The intrinsic relationship between beating rate and proliferation in cardiomyocytes, and whether energy metabolism regulates this relationship, remained unclear.
Does moderate heart rate reduction promote cardiomyocyte proliferation and cardiac regenerative repair in myocardial injury models?
Does moderate heart rate reduction promote cardiomyocyte proliferation and cardiac regenerative repair in myocardial injury models?
Moderate heart rate reduction promotes cardiomyocyte proliferation and cardiac regeneration by shifting energy metabolism towards glycolysis, highlighting a potential therapeutic strategy for long-term cardiac restoration.
Hypothesis-generating for metabolic modulation of repair; leaves open whether moderate heart rate reduction aids human regeneration.
As a biological pump, the heart needs to consume a substantial amount of energy to maintain sustained beating. Myocardial energy metabolism was recently reported to be related to the loss of proliferative capacity in cardiomyocytes (CMs). However, the intrinsic relationship between beating rate and proliferation in CMs and whether energy metabolism can regulate this relationship remains unclear. In this study, we find that moderate heart rate reduction (HRR) induces CM proliferation under physiological conditions and promotes cardiac regenerative repair after myocardial injury. Mechanistically, moderate HRR induces G1/S transition and increases the expression of glycolytic enzymes in CMs. Furthermore, moderate HRR induces a metabolic pattern switch, activating glucose metabolism and increasing the relative proportion of ATP production by the glycolytic pathway for biosynthesis of substrates needed for proliferative CMs. These results highlight the potential therapeutic role of HRR in not only acute myocardial protection but also long-term CM restoration.
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Tan et al. (2022) studied Myocardial injury. Moderate heart rate reduction (HRR) was evaluated on Cardiomyocyte proliferation and cardiac regenerative repair. Moderate heart rate reduction induced cardiomyocyte proliferation and promoted cardiac regenerative repair after myocardial injury by activating glucose metabolism.
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