Why the study?
Does oral sustained action isoprenaline improve outcomes in patients with A-V block and other bradycardias?
Does oral sustained action isoprenaline improve outcomes in patients with A-V block and other bradycardias?
The text introduces the rationale for using oral sustained action isoprenaline in the treatment of A-V block and other bradycardias.
Answers are grounded in this paper and cite their sources.
Rationale for oral sustained-action isoprenaline in A-V block is hypothesis-generating; leaves open its role versus pacing in current practice.
Bradycardia can be due to disturbances in the cardiac conduction system, of which the most com- mon is the atrio-ventricular (a-v) block. Medical treatment of this disorder usually consists in block- ing the vagus-inhibitory effect upon the heart or in stimulation, by administering sympathomimetic substances. During recent years, interest has been focused on the use of sympathomimetic amines, especially isoprenaline hydrochloride In a normal heart this agent, which predominantly acts on the ,B-receptors It has less tendency than adrenaline to stimulate ventricular ectopic foci.
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Nissen et al. (1965) studied this question.
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