Key result
Cholesterol-disrupting agents mitigate disease severity by dissociating lipid raft-associated proteins and lipids.
Cholesterol-rich microdomains (also called lipid rafts), where platforms for signaling are provided and thought to be associated with microbe-induced pathogenesis and lead to cancer progression. After treatment of cells with cholesterol disrupting or usurping agents, raft-associated proteins and lipids can be dissociated, and this renders the cell structure nonfunctional and therefore mitigates disease severity. This review focuses on the role of cholesterol in disease progression including cancer development and infectious diseases. Understanding the molecular mechanisms of cholesterol in these diseases may provide insight into the development of novel strategies for controlling these diseases in clinical scenarios.
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Lin et al. (2015) conducted a review in Cancer and infectious diseases. Cholesterol-rich microdomains (lipid rafts) was evaluated on Disease progression and severity. Cholesterol-disrupting agents dissociate lipid raft-associated proteins and lipids, rendering cell structures nonfunctional and mitigating cancer and infectious disease severity.
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