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Advanced neuroimaging may help select acute stroke patients benefiting from thrombolysis beyond 3 hours.
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Early treatment of ischemic stroke with thrombolytics is associated with improved outcomes, but few stroke patients receive thrombolytic treatment in part due to the 3-hour time window. Advances in neuroimaging may help to aid in the selection of patients who may still benefit from thrombolytic treatment beyond conventional time-based guidelines. In this article the authors review the available literature in support of using advanced neuroimaging to select patients for treatment beyond the 3-hour time window cutoff and explore potential applications and limitations of perfusion imaging in the treatment of acute ischemic stroke.
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Duffis et al. (2011) conducted a review in Acute ischemic stroke. Advanced neuroimaging (including perfusion imaging) to guide thrombolytic therapy vs. Conventional 3-hour time-based guidelines was evaluated. Advanced neuroimaging (including perfusion imaging) may help select acute ischemic stroke patients who can benefit from thrombolytic therapy beyond the conventional 3-hour time window.
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