Key result
Low ABI is linked to lower daily activity volume and ~1.2% greater activity fragmentation.
Why the study?
PAD is associated with lower physical activity, but less is known about its association with daily patterns of activity.
Is abnormal ankle-brachial index (low or high ABI) associated with lower daily volume and higher fragmentation of objectively measured physical activity in Hispanic/Latino adults aged 45–74 years?
Cross-Sectional (n=7,688)
Yes
Is abnormal ankle-brachial index (low or high ABI) associated with lower daily volume and higher fragmentation of objectively measured physical activity in Hispanic/Latino adults aged 45–74 years?
Mean Difference: 1.22
Absolute Event Rate: 24% vs 21%
p-value: p=<.01
In middle-aged and older Hispanic/Latino adults, both low (≤0.90) and high (>1.40) ankle-brachial index values are associated with lower daily physical activity volume, and low ABI is specifically linked to greater activity fragmentation in the afternoon and evening.
Low ABI was associated with lower activity volume and higher fragmentation; hypothesis-generating for prospective studies before clinical adoption.
BACKGROUND: Peripheral artery disease (PAD) is associated with lower physical activity but less is known about its association with daily patterns of activity. We examined the cross-sectional association between ankle-brachial index (ABI) and objectively measured patterns of physical activity among Hispanic/Latino adults. METHODS: We analyzed data from 7 688 participants (aged 45-74 years) in the Hispanic Community Health Study/Study of Latinos. ABI was categorized as low (≤0.90, indicating PAD), borderline low (0.91-0.99), normal (1.00-1.40), and high (>1.40, indicating incompressible ankle arteries). Daily physical activity metrics derived from accelerometer data included: log of total activity counts (LTAC), total log-transformed activity counts (TLAC), and active-to-sedentary transition probability (ASTP). Average differences between ABI categories in physical activity, overall and by 4-hour time-of-day intervals, were assessed using linear regression and mixed-effects models, respectively. RESULTS: In Hispanic/Latino adults, 5.3% and 2.6% had low and high ABIs, respectively. After adjustment, having a low compared to a normal ABI was associated with lower volume (LTAC = -0.13, p < .01; TLAC = -74.4, p = .04) and more fragmented physical activity (ASTP = 1.22%, p < .01). Having a low ABI was linked with more fragmented physical activity after 12 pm (p < .01). Having a high ABI was associated with lower volumes of activity (TLAC = -132.0, p = .03). CONCLUSIONS: Having a low or high ABI is associated with lower and more fragmented physical activity in Hispanic/Latino adults. In adults with low ABI, physical activity is more fragmented in the afternoon to evening. Longitudinal research is warranted to expand these findings to guide targeted interventions for PAD or incompressible ankle arteries.
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Chiu et al. (2023) conducted a cross-sectional in Peripheral artery disease (PAD) and ankle-brachial index (ABI) abnormalities (n=7,688). Low ankle-brachial index (ABI ≤0.90, indicating peripheral artery disease) vs. Normal ankle-brachial index (ABI 1.00-1.40) was evaluated on Daily patterns of physical activity: log of total activity counts (LTAC), total log-transformed activity counts (TLAC), and active-to-sedentary transition probability (ASTP / activity fragmentation) (MD 1.22% for ASTP (LTAC MD -0.13; TLAC MD -74.4), p=<.01). Low ankle-brachial index (≤0.90) was associated with lower daily activity volume (LTAC MD -0.13, p<.01; TLAC MD -74.4, p=.04) and 1.22% higher activity fragmentation (p<.01) vs normal ABI.
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