Key result
Family history of MI is linked to ~58% higher 12-year CHD mortality in men.
Cohort
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We investigated the impact of family history of myocardial infarction on 12-year coronary heart disease mortality. Men and women with a family history had an increased risk for coronary heart disease death, irrespective of other risk factors (RR = 1.58; 95% CI = 1.17-2.13 and RR = 2.12; 95% CI = 1.11-4.05, respectively). Women with a family history seemed to be more susceptible to the detrimental effects of smoking; not to the effects of other risk factors. We found no effect modification by family history in men.
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Boer et al. (1999) conducted a cohort in Coronary heart disease. Family history of myocardial infarction vs. No family history of myocardial infarction was evaluated on 12-year coronary heart disease mortality (RR 1.58 (men); RR 2.12 (women), 95% CI 1.17-2.13 (men); 1.11-4.05 (women)). Family history of MI increased 12-year CHD mortality in men (RR 1.58; 95% CI 1.17-2.13) and women (RR 2.12; 95% CI 1.11-4.05) independent of other risk factors.
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