Key result
Angiotensin II down-regulated nephrin expression via Notch1 activation and nuclear translocation of Snail in experimental models and human diabetic nephropathy.
Population
Isolated perfused rat kidneys, cultured human podocytes, Zucker diabetic fatty rats, and patients with…
Comparison
Pharmacological inhibition of the… vs Untreated/control
Design
Preclinical
Authors
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May support RAS inhibitor benefits via Notch1/Snail in diabetic nephropathy; hypothesis-generating for targeted therapies in patients.
Angiotensin II contributes to diabetic nephropathy by down-regulating nephrin expression via the Notch1/Snail pathway, which can be reversed by renin-angiotensin system inhibitors.
Gagliardini et al. (2013) studied Diabetic nephropathy. Angiotensin II was evaluated on Nephrin expression and Notch1/Snail pathway activation. Angiotensin II down-regulated nephrin expression via Notch1 activation and nuclear translocation of Snail in experimental models and human diabetic nephropathy.
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