Attention recently has been directed by J. H. Wright¹to the existence of a malignant tumor the unit of which is to be regarded as an undifferentiated nerve-cell, hence the neoplasmic designation "neuroblastoma," or, less happily, "neurocytoma." The cells of the tumor are associated, as a rule, with delicate fibrils which do not correspond in their staining reactions with neuroglia, collagen or fibroglia, and are provided with rather small, richly chromatic nuclei and scarcely perceptible cytoplasm. The fibrils are arranged in parallel bundles in intimate association with clumps of cells and, in places, the cells are so disposed as to surround tangled masses of fibrils; hence, in equatorial section they give the appearance of rosettes. In the absence of rosettes the tumor might easily be mistaken for a small round-cell sarcoma, under which designation, indeed, most of the cases in the literature have been recorded. The tardy recognition of
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Douglas Symmers (1913) studied this question.