Key result
Lung cancer was associated with pseudo-myocardial infarction ECG changes, including ST-segment elevation and T-wave inversion, in patients without cardiac anomalies.
Why the study?
Do lung cancer patients exhibit variations in electrocardiogram (ECG) compared to healthy controls?
Cross-Sectional (n=140)
Do lung cancer patients exhibit variations in electrocardiogram (ECG) compared to healthy controls?
Lung cancer patients without cardiac history may exhibit pseudo-myocardial infarction ECG changes such as ST-segment elevation and T-wave inversion, likely due to autonomic dysfunction.
Answers are grounded in this paper and cite their sources.
May prompt consideration of lung cancer in unexplained pseudo-MI ECGs; hypothesis-generating Level 5 observation requiring prospective validation.
Lung cancer subjects undergo fatigue because of chronic stress, which affects their autonomic nervous system activity. The appearance of pseudo-myocardial infarction and T-wave inversion with no clinical symptoms were also detected in lung cancer condition. The present work aims to identify any variation in electrocardiogram (ECG) of lung cancer subjects in comparison with that of healthy controls. The lead II ECG (band-pass filtered from 0.5 to 35 Hz and sampled at 200 Hz) was recorded for 5 minutes using MP45 (Biopac System Inc, Goleta, CA) from 110 consecutive lung cancer subjects and 30 healthy controls in supine position. Acknowledge 4.0 (Biopac System Inc) software was used to study the ECG parameters. ST-segment elevation of 0.2 and 1 mV and T-wave inversion was found in ECG of lung cancer subjects without any clinical history of cardiac disorder. Subjects 1 and 2 were observed with ST-segment elevation. Subject 3 exhibited biphasic T-waveform, and subjects 4 to 8 revealed T-wave inversion in ECG. The ECG of lung cancer subjects varies from healthy controls’ ECG. ST-segment elevation similar to myocardial infarction and T-wave inversion existed in a few subjects who had no cardiac anomaly. These unique changes in ECG suggested a high level of fatigue due to a higher amount of cholinergic and adrenergic neurotransmitters secreted, leading to increased sympathetic activity and decreased parasympathetic activity.
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Shukla et al. (2017) conducted a cross-sectional in Lung cancer (n=140). Lung cancer vs. Healthy controls was evaluated on Variation in electrocardiogram (ECG) parameters. Lung cancer was associated with pseudo-myocardial infarction ECG changes, including ST-segment elevation and T-wave inversion, in patients without cardiac anomalies.
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