Towards an animal model of amiodarone-induced thyroid dysfunction

Key Points

• To evaluate and establish effective animal models for investigating the pathophysiological mechanisms underlying amiodarone-induced thyroid dysfunction.
• Reviewed experimental approaches and laboratory animal regimens used to replicate amiodarone-induced hypothyroidism and thyrotoxicosis.
• Examined pharmacological effects of chronic amiodarone administration and associated iodine excess on thyroid hormone metabolism.
• Identified key challenges in replicating human-like amiodarone-induced thyroid abnormalities across standard rodent models.
• Highlighted the complex interplay between drug toxicity and high iodine content in altering thyroid hormone synthesis and peripheral conversion.