Key result
A theoretical model of actin-myosin networks based on tension-dependent motor detachment and actin filament rupture quantitatively explains the reduction of elastic modulus under oscillatory strain.
Describes a mechanosensing mechanism in actin-myosin networks that explains the reduction of elastic modulus under oscillatory strain.
We describe the mechanosensing mechanism in actin–myosin networks based on the tension dependence of the motor detachment rate and a possibility of rupture of actin filaments under strain. Both effects, operating at different orientations to the applied strain, induce orientational anisotropy of the network. The theory is applied to explain quantitatively the drastic reduction of the elastic modulus under oscillatory strain observed in the experiment.
No takes yet. Share an insight, caveat, or question.
Morozov et al. (2012) studied this question. A theoretical model of actin-myosin networks based on tension-dependent motor detachment and actin filament rupture quantitatively explains the reduction of elastic modulus under oscillatory strain.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: