Persistent Mercury in Nerve Cells 16 Years After Metallic Mercury Poisoning

Hargreaves R.J., Evans J. G., Janota I., Magos L. & Cavanagh J. B. (1988) Neuropathology and Applied Neurobiology 14, 443–452 Persistent mercury in nerve cells 16 years after metallic mercury poisoning A male subject, after exposure to mercury metal at work in 1968, developed classical signs of mercurialism from which he made a slow clinical recovery. He subsequently developed psychoneurotic symptoms and became an alcoholic; he never returned to work and died in 1984. No histological changes relevant to mercury intoxication were found in the brain, but staining by Danscher & Schroeder's method for mercury showed many positively staining lysosomal dense bodies in a large proportion of nerve cells, and the presence of mercury was confirmed by elemental X–ray analysis. The mercury content of the brain was increased, much of it being present in colloidal form.