Key result
Early elevated cortisol and IL-6 levels positively impacted HRQoL in SAH survivors, though 47.2% of those with good clinical outcomes still had reduced HRQoL at 6 months.
Why the study?
To evaluate the impact of aneurysmal subarachnoid hemorrhage on surviving patients' health-related quality of life regarding cortisol and interleukin-6 alterations, and to identify potential clinical predictors of better HRQoL.
Cohort (n=50)
No
Early cortisol and IL-6 levels may predict health-related quality of life in patients surviving aneurysmal subarachnoid hemorrhage, many of whom experience reduced HRQoL despite good clinical outcomes.
Early cortisol/IL-6 elevation may associate with better HRQoL after SAH; hypothesis-generating and requires validation before clinical use.
OBJECTIVE: To highlight the impact of aneurysmal subarachnoid hemorrhage (SAH) on surviving patients' health-related quality of life (HRQoL) with respect to cortisol and interleukin (IL)-6 alterations and also to identify possible clinical predictors for a better HRQoL. METHODS: Fifty surviving patients treated in our hospital for aneurysmal SAH in a 2-year period with sufficient HRQoL data were enrolled. A good clinical outcome was represented by the modified Rankin Scale (mRS) 0 to 2. The patient's HRQoL was assessed using the Short Form health survey questionnaire, the Beck Depression Inventory, and the Daily Fatigue Impact Scale at 6 and 12 months. The results were analyzed regarding possible correlation to 24-hour urinary free cortisol, serum, and cerebrospinal fluid IL-6 levels. RESULTS: A reduction of HRQoL in up to 35% of survivors was observed at 6 months and in a high proportion of patients (47.2%) with an assumable good outcome (mRS 0-2). Reduced HRQoL in survivors was found in terms of SF-36 (34.9%), depression (26.8%), and fatigue (14%) at 6 months and 18.4%, 39.4%, and 18.9% at 12 months, respectively. Improvement was recorded at 12 months, mainly in SF-36. Early elevated 24-hour urinary free cortisol and IL-6 levels showed a significant positive impact on HRQoL. CONCLUSIONS: Early cortisol and IL-6 levels may predict patients' HRQoL after SAH. Twelve months after SAH, a considerable percentage of patients with a presumably good outcome (mRS 0-2) had a lower HRQoL compared with the general population. Implementing corresponding tests at discharge and 12-month follow-up is recommended.
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Ridwan et al. (2019) conducted a cohort in Aneurysmal subarachnoid hemorrhage (SAH) (n=50). Early elevated 24-hour urinary free cortisol and IL-6 levels was evaluated on Health-related quality of life (HRQoL) assessed using SF-36, Beck Depression Inventory, and Daily Fatigue Impact Scale. Early elevated cortisol and IL-6 levels positively impacted HRQoL in SAH survivors, though 47.2% of those with good clinical outcomes still had reduced HRQoL at 6 months.
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