What question did this study set out to answer?

This research aims to investigate how β-adrenoceptor blocking drugs affect heart rate responses to glyceryl trinitrate in normal and ischaemic heart disease subjects.

February 1, 1974British Journal of Clinical PharmacologyOpen Access

OBSERVATIONS ON THE EFFECT OF β‐ADRENOCEPTOR BLOCKING DRUGS ON GLYCERYL TRINITRATE TACHYCARDIA

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Why the study?

Do beta-blockers (practolol and propranolol) reduce glyceryl trinitrate-induced tachycardia in normal subjects and patients with ischaemic heart disease?

Population

Normal subjects and patients after an acute episode of ischaemic heart disease

Comparison

Oral administration of practolol or propranolol vs Placebo

Design

Other

Authors

JEJ M EkueTropical Diseases Research Centre RSR.G. ShanksQueen's University Belfast MWMark WalshDalhousie University

Discussion

Member takes

Implication

May blunt reflex tachycardia post-acute IHD; leaves open outcome benefits in prospective trials.

Key Points

This research aims to investigate how β-adrenoceptor blocking drugs affect heart rate responses to glyceryl trinitrate in normal and ischaemic heart disease subjects.
Administered 0.5 mg glyceryl trinitrate sublingually to assess heart rate response in normal subjects.
Conducted a randomized trial comparing practolol and propranolol on heart rate response after glyceryl trinitrate administration.
Evaluated the effects of practolol in ischaemic heart disease patients versus placebo during standing and glyceryl trinitrate administration.
Heart rate significantly increased with glyceryl trinitrate administration in normal subjects.
Practolol and propranolol reduced heart rate increase, with propranolol showing a significantly greater effect (exact metrics not provided).
Practolol (300 mg) reduced heart rate increases in ischaemic heart disease patients compared to placebo, indicating effective management of tachycardia.

Structured PICO

Do beta-blockers (practolol and propranolol) reduce glyceryl trinitrate-induced tachycardia in normal subjects and patients with ischaemic heart disease?

Population

Normal subjects and patients after an acute episode of ischaemic heart disease

Intervention

Oral administration of practolol (300 mg twice daily) or propranolol

Comparator

Placebo

Outcome

Increase in heart rate produced by glyceryl trinitrate (0.5 mg sublingual) and standingsurrogate

Beta-blockers effectively blunt the reflex tachycardia induced by glyceryl trinitrate and standing in both normal subjects and patients with recent ischaemic heart disease.

Cite This Study

Ekue et al. (1974) studied this question.

synapsesocial.com/papers/6a71e22b2163a0a01bc5d421 https://doi.org/10.1111/j.1365-2125.1974.tb00201.x

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OBSERVATIONS ON THE EFFECT OF β‐ADRENOCEPTOR BLOCKING DRUGS ON GLYCERYL TRINITRATE TACHYCARDIA

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

OBSERVATIONS ON THE EFFECT OF β‐ADRENOCEPTOR BLOCKING DRUGS ON GLYCERYL TRINITRATE TACHYCARDIA

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider