According to a chiral memory protocol, a chiral glycolic acid equivalent, the butane-2,3-diacetal-desymmetrized glycolate 2, is obtained from chiral 3-halopropane-1,2-diols 1. Compound 2 is a new and effective building block for the synthesis of mono- and dialkylated α-hydroxy acids 3, which constitute a biologically and pharmacologically important structural motif.
No takes yet. Share an insight, caveat, or question.
Dı́ez et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: