Key result
Persons with multiple sclerosis demonstrated weaker, more localized brain connectivity during obstacle avoidance and left laterality during walking compared to healthy controls (p<0.05).
Why the study?
Does walking while avoiding obstacles alter brain connectivity in persons with multiple sclerosis compared to healthy controls?
Cross-Sectional
Does walking while avoiding obstacles alter brain connectivity in persons with multiple sclerosis compared to healthy controls?
Persons with multiple sclerosis exhibit disrupted and inefficient brain connectivity during complex motor-cognitive tasks, highlighting potential targets for rehabilitation.
May link weaker connectivity to gait impairment in MS during complex walking; hypothesis-generating for targeted rehabilitation strategies.
This study investigated effective connectivity and hemispheric asymmetry in persons with multiple sclerosis (pwMS) compared to healthy controls (HC) during two walking conditions: walking alone and walking while avoiding unpredictable obstacles. Cognitive-motor interference (CMI) was analyzed using electroencephalography (EEG) across beta, alpha, and theta frequency bands. Directed functional connectivity was estimated using partial directed coherence (PDC) to assess differences in connectivity patterns between conditions and groups. In healthy controls, obstacle avoidance increased connectivity in motor and cognitive regions including left central (LC), left temporal (LT), and right frontal (RF) regions, p<0.0014. In contrast, pwMS demonstrated weaker and more localized connectivity, primarily in the left central regions (sensorimotor cortices) p<0.0013, suggesting reduced efficiency in brain networks and compensatory mechanisms to maintain task performance. Further, pwMS showed left laterality toward the central region during both walking conditions compared to HC, p<0.05. Correlational analysis revealed that connectivity during obstacle avoidance in HC positively correlated with comfortable walking speed (r =0.57), indicating efficient neural pathways. In pwMS, connectivity showed a negative correlation with walking speed (r $= -0.65$ ), indicating compensatory but inefficient neural engagement. These findings highlight disruptions in brain connectivity during motor-cognitive tasks in pwMS, with potential implications for designing targeted rehabilitation strategies to improve gait and neural efficiency.
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Al-Shargie et al. (2025) conducted a cross-sectional in Multiple Sclerosis. Multiple sclerosis vs. Healthy controls was evaluated on Effective connectivity and hemispheric asymmetry during walking and obstacle avoidance (p=<0.05). Persons with multiple sclerosis demonstrated weaker, more localized brain connectivity during obstacle avoidance and left laterality during walking compared to healthy controls (p<0.05).
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