Key result
Stroke upregulates cerebrovascular vasoconstrictor receptors via ERK1/2 signaling, highlighting a potential therapeutic target.
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Edvinsson et al. (2011) conducted a review in Cerebral ischemia, ischemic stroke, and subarachnoid hemorrhage. Extracellular regulated kinase 1/2 (ERK1/2) pathway targeting was evaluated on Upregulation of vasoconstrictor receptors (ETB, AT1, 5-HT1B/1D) in cerebral artery smooth muscle after stroke.
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