Remission induction is the most intensive course of acute leukemia treatment.There is paucity of contemporary data on outcomes of induction from developing countries.In this study from a tertiary care centre in South India we report induction outcomes for all cases of acute leukemia (n = 109, ALL = 71 and AML = 38) registered in department of Medical Oncology in the calendar year 2015.76 patients were in pediatric age group ( 18 years) and 33 were adults, male to female ratio was 1.6:1.All febrile neutropenia related events were more in AML, with early onset (median day to onset was day 8 in AML vs. day 17 in ALL), higher severity (94% clinically or microbiologically documented infection in AML vs. 61% in ALL), increased fungal infections (25% probable fungal pneumonia in AML vs. 6% in ALL) and consequently with more resource utilization.CR rate for ALL was 70%and 53% for AML.Fatal induction events were recorded in 17.6% ALL and 34.3% AML.Mortality during induction therapy of acute leukemia is high in resource limited settings, higher in AML than ALL, mostly because of infections (74% of induction deaths).There is a vital need for analysis of resources and improvement in supportive care during acute leukemia induction.
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Kayal et al. (2018) studied this question.
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