Structural Studies of Copper(I) Complexes of Amyloid‐β Peptide Fragments: Formation of Two‐Coordinate Bis(histidine) Complexes

The beta bind: Copper(I) binds to amyloid β-peptide fragments (see structure) as a stable bis(histidine), two-coordinate, near-linear complex, even in the presence of potential additional ligands. As has been proposed or assumed in other studies, the copper(I)–peptide complexes react with dioxygen to form the reactive oxygen species H2O2, without the need for a third histidine ligand to promote the chemistry.