This preclinical study demonstrates that salt loading alters renin-like activity in the rat brain, suggesting a physiological role for the central renin-angiotensin system in fluid and electrolyte balance.
Salt loading alters rat brain renin-like activity; leaves open a physiological role for central RAS in fluid balance pending higher-order validation.
The presence and distribution of renin-like activity in hypophysis, pineal gland and some neural tissues were studies in both normal and salt-loaded rats. The Boucher micromethod was used to detect enzymatic activity. In normal rats both the pituitary and pineal glands contained significantly higher values of renin-like activity than did the other tissues examined. In salt-loaded animals there was a significant decrease of the renin-like activity of the glandular tissue while in the other brain areas the activity increased. The results are discussed in terms of the possible physiological role of the central renin-angiotensin system in the regulation of fluid and electrolyte balance.
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Hăulică et al. (1975) studied this question.
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