Comparison of the Therapeutic Efficacy of Oral Doses of Fluconazole and Griseofulvin in a Guinea Pig Model of Dermatophytosis.

Fluconazole (FLCZ) developed by Pfizer Ltd. in the United Kingdom, is a triazole antifungal agent with a broad spectrum of activity. In both oral and intravenous dosing forms, FLCZ is widely used for the treatment of candidiasis, cryptococcosis and several other deep-seated mycoses1'^. In addition, orally administered FLCZhas been reported to be useful for a systemic therapy of dermatophytoses, oropharyngeal candidiosis and other superficial mycoses3~6).