Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 1, 1995Circulation Research

Localization of Atrial Natriuretic Factor Receptors in the Mesenteric Arterial Bed

View Full Paper
Ask AI
Bookmark
Share

Population

Rat mesenteric arteries and surrounding adipose tissue

Design

Preclinical

Authors

HLHéctor De LeónHelicon FoundationMBMarie-Chantal BonhommeInsermGTGaétan ThibaultHeart Failure / Cardiomyopathy

Discussion

Loading...

Member takes

Implication

ANF receptor localization in perivascular adipose tissue may modulate mesenteric tone; leaves open human translation and therapeutic targeting.

Structured PICO

P
Population
Rat mesenteric arteries and surrounding adipose tissue
I
Intervention
Radioligand binding experiments with 125I-ANF, 125I-[Sar1,Ile8]Ang II, and 125I-ET-1
O
Outcome
Tissue localization and binding characteristics of ANF, Ang II, and ET-1 receptorssurrogate

Receptors for ANF and Ang II are primarily localized in the surrounding adipose tissue rather than the mesenteric artery itself, unlike ET-1 receptors which are abundant in both.

Cite This Study

León et al. (1995) studied this question.

synapsesocial.com/papers/6a71f5e184cc45bb7be009c2https://doi.org/10.1161/01.res.77.1.64
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Synthetic atrial natriuretic factor does not dilate resistance-sized arteries.1986 · 45 citations
  2. 2Simultaneous perfusion of rat isolated superior mesenteric arterial and venous beds: comparison of their vasoconstrictor and vasodilator responses to agonists1990 · 80 citations
  3. 3Cellular Localization of Angiotensinogen Gene Expression in Brown Adipose Tissue and Mesentery: Quantification of Messenger Ribonucleic Acid Abundance Using Hybridization in Situ*1987 · 150 citations
  4. 4Endothelin: a new challenge1992 · 154 citations