SummaryTwenty-three strains of fibroblasts derived from normal rabbit and chick embryo tissue were serially propagated on glass in a variety of media. All except 3 strains failed to proliferate for more than 8 to 12 subcultures. The 3 successful strains were derived from adult testis, embryonic skin-muscle and adult muscle respectively and continue to proliferate at a constant rate after 38 to 61 subcultures. Vaccinia virus multiplies in all 3 strains of fibroblasts resulting in the complete destruction of cells.
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Haff et al. (1956) studied this question.